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Table 1 Renal specific factors contributing to kidney fibrosis

From: Fibrosis in the kidney: is a problem shared a problem halved?

  Factor Cause
1 Complexity Kidney consists of ~20 different cell types
2 Poor capacity for regeneration Damaged glomeruli do not regenerate
Each nephron is anatomically distinct
3 Toxins Protein leakage and tubule uptake
Uraemic milieu (>50 putative or proven toxins)
4 Hypoxia High tubule demand for oxygen
5 Arterial pressure dependent Pivotal role of renin-angiotensin-aldosterone system