Table 1 Renal specific factors contributing to kidney fibrosis
From: Fibrosis in the kidney: is a problem shared a problem halved?
| Â | Factor | Cause |
|---|---|---|
1 | Complexity | Kidney consists of ~20 different cell types |
2 | Poor capacity for regeneration | Damaged glomeruli do not regenerate Each nephron is anatomically distinct |
3 | Toxins | Protein leakage and tubule uptake Uraemic milieu (>50 putative or proven toxins) |
|  |    Proteinuria |  |
|  |    Uraemia |  |
4 | Hypoxia | High tubule demand for oxygen |
5 | Arterial pressure dependent | Pivotal role of renin-angiotensin-aldosterone system |