Histological analysis of the resected esophagus with predominant inflammatory pattern. Absence of neoepithelium, granulation tissue with an important inflammatory cell infiltrate of the submucosal layer; submucosal fibrosis is highlighted by Masson’s trichrome staining. (A1) Untreated swine, hematoxylin-eosin-safran (HES), original magnified x12.5. (A2) Untreated swine, Masson’s trichrome, original magnified x12.5. (B1) Treated by N-acetylcysteine (NAC), HES, original magnified x25. (B2) Treated by NAC, Masson’s trichrome, original magnified x25.