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Table 1 Overview of the major integrin sub-units and respective ligands involved in endothelial progenitor cell biology.

From: Endothelial progenitor cells and integrins: adhesive needs

Integrin Main ligand Role on EPC biology References
α4β1 FN; VCAM-1 Bone marrow retention and/or mobilization;
homing and/or adhesion to angiogenic sites
[63, 72]
α5β1 FN Homing and/or adhesion to angiogenic sites;
invasion and migration;
differentiation and paracrine/juxtacrine interaction
[44, 69, 83, 9698]
α6β1 Laminin Homing and/or adhesion to angiogenic sites;
invasion
[56, 87]
β2 integrins Fibrin(ogen); ICAM-1/2 Homing and/or adhesion to angiogenic sites;
transendothelial migration
[7274, 90, 91]
αvβ3 RGD Homing and/or adhesion to angiogenic sites;
bone marrow retention and/or mobilization (β3 subunit)
[69, 88, 98]
αvβ5 RGD Homing/adhesion to angiogenic sites;
differentiation and paracrine and/or juxtacrine interaction (β5 subunit)
[88, 89, 98, 99]
  1. EPC: endothelial progenitor cell; FN: fibronectin; ICAM-1/2: intercellular adhesion molecule 1/2; RGD: arginine-glycine-aspartate motif; VCAM-1: vascular cell adhesion molecule 1.