Table 1 Overview of the major integrin sub-units and respective ligands involved in endothelial progenitor cell biology.

α4β1

FN; VCAM-1

Bone marrow retention and/or mobilization;

homing and/or adhesion to angiogenic sites

[63, 72]

α5β1

FN

Homing and/or adhesion to angiogenic sites;

invasion and migration;

differentiation and paracrine/juxtacrine interaction

[44, 69, 83, 96–98]

α6β1

Laminin

Homing and/or adhesion to angiogenic sites;

invasion

[56, 87]

β2 integrins

Fibrin(ogen); ICAM-1/2

Homing and/or adhesion to angiogenic sites;

transendothelial migration

[72–74, 90, 91]

αvβ3

RGD

Homing and/or adhesion to angiogenic sites;

bone marrow retention and/or mobilization (β3 subunit)

[69, 88, 98]

αvβ5

RGD

Homing/adhesion to angiogenic sites;

differentiation and paracrine and/or juxtacrine interaction (β5 subunit)

[88, 89, 98, 99]