From: Interventions in Wnt signaling as a novel therapeutic approach to improve myocardial infarct healing
Study | Intervention | Effect on Wnt pathway | Outcome |
---|---|---|---|
Barandon et al. [23] | FrzA overexpression | Inhibition | Reduced MI size and improved cardiac function |
Barandon et al. [56] | sFRP-1 overexpression | Inhibition | Decreased cardiac rupture and scar size |
He et al. [54] | sFRP-2 administration | Inhibition | Improved cardiac function |
Kobayashi et al. [62] | sFRP-2 deletion | ? | Decreased fibrosis and improved cardiac function |
Matsushima et al. [63] | sFRP-4 i.m. administration | Inhibition | Improved cardiac function |
Saraswati et al. [64] | Pyrvinium administration | Inhibition | Decreased LVIDD |
Laeremans et al. [65] | UM206 administration | Inhibition | Decreased infarct size and improved cardiac function |
Hahn et al. [52] | β-catenin | Stimulation | Decreased infarct size |
 | overexpression |  |  |
Zelarayan et al. [68] | Cardiomyocyte specific | Â | Â |
 | - β-catenin depletion | - Inhibition | - Improved cardiac function |
 | - β-catenin stabilization | - Stimulation | - Opposite effects |