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Table 1 Overview of studies intervening in the Wnt pathway following MI

From: Interventions in Wnt signaling as a novel therapeutic approach to improve myocardial infarct healing

Study

Intervention

Effect on Wnt pathway

Outcome

Barandon et al. [23]

FrzA overexpression

Inhibition

Reduced MI size and improved cardiac function

Barandon et al. [56]

sFRP-1 overexpression

Inhibition

Decreased cardiac rupture and scar size

He et al. [54]

sFRP-2 administration

Inhibition

Improved cardiac function

Kobayashi et al. [62]

sFRP-2 deletion

?

Decreased fibrosis and improved cardiac function

Matsushima et al. [63]

sFRP-4 i.m. administration

Inhibition

Improved cardiac function

Saraswati et al. [64]

Pyrvinium administration

Inhibition

Decreased LVIDD

Laeremans et al. [65]

UM206 administration

Inhibition

Decreased infarct size and improved cardiac function

Hahn et al. [52]

β-catenin

Stimulation

Decreased infarct size

 

overexpression

  

Zelarayan et al. [68]

Cardiomyocyte specific

  
 

- β-catenin depletion

- Inhibition

- Improved cardiac function

 

- β-catenin stabilization

- Stimulation

- Opposite effects

  1. LVIDD, left ventricular internal diameter in diastole; MI, myocardial infarction; sFRP, soluble frizzled-related protein.