Figure 2From: Diabetic angiopathy and angiogenic defectssFllt1 plays as endogenous inhibitor of VEGF signaling by trapping free-VEGF. VEGF signaling is strictly regulated by endogenous molecules, including sFlt1. sFlt1 binds to and sequesters VEGF from cell-surface VEGF receptors, subsequently VEGF modulated pro-angiogenesis signal is inhibited.Back to article page