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Figure 1 | Fibrogenesis & Tissue Repair

Figure 1

From: Diabetic angiopathy and angiogenic defects

Figure 1

Schematic image of angiogenesis switch. Angiogenesis results from the balanced functions of pro-angiogenic and anti-angiogenic molecules. Defects in the angiogenic balance lead to a shift toward either excessive angiogenesis or anti-angiogenesis. CSF, colony-stimulating factor; EGF, epidermal growth factor; FGF, fibroblast growth factor; FLT1, fms-related tyrosine kinase 1; HGF, hepatocyte growth factor; IGF, insulin-like growth factor; MMP, matrixmetalloproteinases, PDGF, platelet-derived growth factor; PECAM-1, platelet endothelial cell adhesion molecular (also known as CD31); PEDF, pigment epithelium-derived factor; TGFβ, transforming growth factor-β; TIMP, tissue inhibitor of metalloproteinases; TNFa, tumor necrosis factor-α; VE, vascular endothelial; VEGF, vascular endothelial growth factor.

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