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Table 1 Both ERV1 and ALR were initially reported to be encoded by a 1.2 kb gene with protein products of 117 and 125 amino acids, respectively

From: Augmenter of liver regeneration

Protein Species Gene size Chromosomal Amino acids/ Mito. Leader Function Ref.
Name    Location Molecular weight Sequence   
ERV1 S. Cerevisiae 1.2 kb VII 117/~14 kDa No OxPhos/growth 24
ERV1 S. Cerevisiae 1.2 kb VII 189/~22 kDa Yes OxPhos/growth 25
ERV2 S. Cerevisiae 1.2 kb XVI 196/~22 kDa No Sulfhydryl oxidase 28, 29
ALR Rat 1.2 kb 10 125/~15,081 No HR/Anti-atrophy 19
ALR Rat ND ND 198/~22 kDa Yes HR/Anti-atrophy 19, 20
ALR Mouse 6.7 kb 17 198/~22 kDa Yes HR/Anti-atrophy 20
ALR Human ND 16 205/~22 kDa Yes HR/Anti-atrophy 20, 23
  1. Subsequent investigation demonstrated that these proteins are larger in size with amino-terminal mitochondrial targeting sequence. Another yeast protein (ERV2 located in microsomes), homologous to ERV1, was later discovered. ALR is present as a single gene copy located on mouse chromosome 17 or human chromosome 16 in polycystic kidney disease 1 (PKD1) region [20, 23]. The functions indicated for ALR and ERV proteins are the ones discovered initially. Other functions of these proteins are described in the text in relevant sections. HR, hepatic regeneration; ND, not determined; OxPhos, oxidative phosphorylation.