Table 1 High-throughput studies in HCV patients analyzing differential gene expression based on fibrosis stage
From: Genomics and proteomics in liver fibrosis and cirrhosis
1st author | Year | # Patients | # Controls | Specimen | Methods | # Differentially expressed genes | Main pathways involved | Most differentially regulated genes | ⇑/⇓ | Reference |
|---|---|---|---|---|---|---|---|---|---|---|
Huang | 2006 | 121 | 312 | Blood | SNP microarray | 1,609 | N/A | DEAD-box popypeptide 5 (DDX5) SNP Carnitine palitoyltransferase 1A (CPT1A) SNP | ⇑ ⇑ | 81 |
Diamond | 2007 | 22 | 4 | Liver tissue | LC-ESI-FTICR MS/MS | 210 | Amino acid, carbohydrate and lipid metabolism Oxidative phosphorylation Oxidative stress | N/A | N/A N/A N/A | 72 |
White | 2007 | 23 | 21 | Serum | 2-DE/LC-Q-TOF MS/MS | 7 | N/A | Alpha-2-macroblobulin Haptoglobin Fragment of albumin Serum retinol binding protein (SRBP) Complement 4 Apolipoprotein A-I (Apo A1) Apolipoprotein A-IV (Apo A4) | ⇑ ⇑ ⇑ ⇓ ⇓ ⇓ ⇓ | 74 |
Gangadharan | 2007 | 11 | 4 | Serum | 2-DE-Q-TOF/CapLC MS/MS | 83 | Plasmin-associated Hepatic synthetic function HGF-releated Lipid metabolism Immune system related | Alpha-2-macroblobulin Inter-alpha-trypsin inhibitor heavy chain 4 Albumin Transthyretin Complement C3 and C4 Factor H-related protein 1 Alpha-1 antichymotrypsin Haptoglobin Apolipoprotein L-I Beta 2 glycoprotein CD5 antigen like IgA1+IgG2 heavy chain and Ig light chain regions | ⇑ ⇓ ⇓ ⇓ ⇓ ⇓ ⇓ ⇓ ⇓ ⇓ ⇑ ⇓ ⇓ ⇑ ⇑ | 76 |
Mölleken | 2009 | 7 | 7 | microdissections | 2-DE/LC-ESI-Ion trap MS/MS | 35 | Cell structure | Tropomyosin alpha Tropomyosin beta Microfibtil-associated glycoprotein 4 Calpoin 1 Transgelin Tropomyosin alpha 4 Actin alpha 1 Vimentin | ⇑ ⇑ ⇑ ⇑ ⇑ ⇑ ⇑ ⇑ | 73 |