Figure 3

Knockdown thrombospondin 1 (TSP1) expression through small interfering (si)RNA transfection alters the contractile characteristics and protein expression in both normal and systemic sclerosis (SSc) fibroblasts. (a) The contractile ability of SSc and normal fibroblasts were reduced following siRNA transfection. (b) Western blot demonstrating a reduction in protein expression following siRNA transfection.