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Table 2 Identification of Integra® (IT) matrix targeting peptides from libraries eluted by acid, acid salt and chondroitin sulfatea

From: A phage-targeting strategy for the design of spatiotemporal drug delivery from grafted matrices

IT1b R3 (pH 2) IT6c R3 (pH 2) IT6 R (GAGd) IT7c R3 (pH 2) IT7 R3 (GAG)
BSA IT1 (Figure 3) BSAe IT6-BA (Figure 4A) BSA IT6-CG (Figure 4B) BSA IT7-BA (Figure 5A) BSA IT7-CG (Figure 5B)
3.2 CTES APYFC A-1 CNPLHRQHC CG-1 CLSTSSKSC BA-1 HWHDWMWSWRRD CG-1 AYYPQNHKSNAE
3.4 CPDA NNGNC A-2 CFKHSSHQC CG-2 CLSTSSKSC BA-2 SMWPWYYSQWAR CG-2 APQYQHNQATHT
3.7 CNMA QT NMC A-3 CPPTPLSLC CG-3 CLSTSSKSC BA-3 TLGDRYSTKHPI CG-3 SITWTHHPGALQ
3.8 CPNA NLGTC A-4 CINASKPLC CG-4 CQTSANTQC BA-4 SFSTMNTAPGGS CG-4 AGLHPRSLESLP
4.2 CINS FYAQC A-5 CNRMVQPMC CG-5 CGVPAGSTC BA-5 WYMPWWSAGQAA CG-5 HPGNRSLDPLNH
4.3 CKSA IS SSC A-6 CNLALTQAC CG-6 CLSTSSKSC BA-7 QKKIRKRPHVKR CG-6 LLADTTHHRPWT
4.4 CVPQYS SQC A-7 CFKHSSHQC CG-7 CLSTSSKSC BA-8 GAFHKHHHARLI CG-7 ATGKPTRLESHV
4.5 CQPKAVNHC A-8 CQEPRSNAC CG-8 CLATKLHNC BA-9 WYMPWWSAGQAA CG-8 NPSNLYRQPAMT
4.7 CPVS PS GAC A-9 CPSHHLESC CG-9 CLSTSSKSC BA-10 WNRSPLPDYGAA CG-9 SKAHDISQRQPP
4.8 CSNA SRPFC A-10 CNPLHRQHC CG-10 CDGVSTKHC BA-11 SLWQRWFPVLDH CG-10 VNRIPGENLSSP
4.10 CNPA LS THC A-11 CSKTFPVRC CG-11 CLSTSSKSC BA-12 HWHDWMWSWRRD CG-11 AYYPQNHKSNAE
4.13 CGKA GLPLC A-12 CFKHSSHQC CG-12 CLSTSSKSC BA-13 DLALRNPTPSDP CG-12 SNQPAPALFHQL
4.14 CPTHP PFQC - - CG-13 CIKNPTKYC BA-14 SHALPLTWSTAA CG-13 YSPASKSPVPSL
4.15 CES SAIRYC AS-1 CFKHSSHQC CG-14 CLSTSSKSC BA-15 WHYNSWYRWPVM CG-14 SVSVGMKPSPRP
4.18 CNNGTS RLC AS-2 CFKHSSHQC CG-15 CMPSPSLK - - CG-15 SVSVGMKPSPRP
4.19 CPS QTHP TC AS-3 CTYPFHASC - - - - - -
4.20 CTNQQRHTC - - - - - - - -
  1. aThe sequences of peptides isolated using the biopanning strategies IT1, IT6 and IT7 are presented along with their code numbers for reference.
  2. bIT1 was screened against intact matrix and only acid eluates were evaluated.
  3. cIT6 and IT7 used both acid and GAG elutions.
  4. dGAG = glycosaminoglycan.
  5. eBSA = bovine serum albumin.