Centrilobular emphysema combined with pulmonary fibrosis results in improved survival

Table 4 Clinical characteristics of patients with emphysema score (ES) > 2 based on type of emphysema.

Variable	ES > 2 Paraseptal (n= 7)	ES > 2 Mixed (n= 8)	ES > 2 Centrilobular (n= 13)	P value
Age years; median [1st, 3rd]	57 [51, 63]	59 [57, 63]	54 [49, 62]	NS*
Gender:
Male, n	7	8	2	< 0.001^†
Female, n	0	0	11
Race:
Caucasian, n	3	6	7
African-American, n	3	2	6	NS^†
Other, n	1	0	0
Smoking packs/years; median [1st, 3rd]	14 [0, 38]	40 [38, 46]	45 [25, 60]	< 0.05*
Right heart catheterization:
Performed, n (%)	5 (71)	6 (75)	6 (46)	NS^†
Mean PAP mm Hg; median [1st, 3rd]	32 [21, 34]	31 [29, 33]	25 [22, 31]	NS*
Surgical lung biopsy:
Performed, n (%)	6 (86)	5 (63)	9 (70)	NS^†
UIP, n	6	4	4	< 0.05^†
Fibrotic NSIP, n	0	1	5
FVC % predicted; median, [1st, 3rd]	57 [50, 60]	59 [51, 63]	71 [58, 84]	NS*
TLC % predicted; median, [1st, 3rd]	58 [51, 64]	60 [52, 69]	72 [64, 86]	0.05
DL_CO % predicted; median, [1st, 3rd]	25 [21, 31]	28 [23, 34]	27 [18, 37]	NS*

*Kruskal-Wallis one-way ANOVA; ^†Chi-square test.
Paraseptal, paraseptal emphysema; mixed, mixed centrilobular and paraseptal emphysema; centrilobular, centrilobular emphysema; mean PAP, mean pulmonary artery pressure; UIP, usual interstitial pneumonia; NSIP, non-specific interstitial pneumonia; FVC, forced vital capacity; TLC, total lung capacity; DL_CO, diffusing capacity for carbon monoxide; NS, not significant (P > 0.05).

ISSN: 1755-1536