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Table 2 Clinical characteristics of patients based on emphysema score.

From: Centrilobular emphysema combined with pulmonary fibrosis results in improved survival

Variable ES 0
(n= 48)
0 < ES ≤ 2
(n= 26)
ES > 2
(n= 28)
P value
Age years; median [1st, 3rd] 62 [58, 68] 61 [53, 67] 57 [51, 62] NS*
Gender:     




Male, n




Female, n
31
17
18
8
17
11
NS
Race:     




Caucasian, n 38 15 16  




African-American, n 8 9 11 NS




Other, n 2 2 1  
Medication:     




Prednisone, n 40 26 22 NS




Azathioprine, n 24 13 12 NS




Mycophenolate, n 14 9 4 NS




N-Acetylcysteine, n 22 13 7 NS




ACE Inhibitor, n 10 6 3 NS




Statin, n 20 14 11 NS
Smoking:     




Current smoker, n (%) 1(2) 2 (7) 4 (14) NS




Ever-smoker, n (%) 27 (56) 21 (81) 24 (86) < 0.01




Pack/years, median [ 1st, 3rd] 5 [0, 20] 20 [10, 39] 40 [20, 50] < 0.0001*
Fibrosis score:     




< 10%, n 7 5 2  




10 - 40%, n 27 16 19 NS




> 40%, n 14 5 7  
Right heart catheterization:     




Performed, n (%) 37 (77) 22 (84) 17 (61) NS




Mean PAP mm Hg; median [ 1st, 3rd] 21 [18, 24] 29 [22, 40] 29 [22, 33] < 0.001*
Surgical lung biopsy:     




Performed, n (%) 36 (75) 17 (65) 20 (71) NS




UIP, n 32 14 14 NS




Fibrotic NSIP, n 4 3 6  




Lung transplantation performed, n (%) 19 (39) 6 (23) 9 (32) NS
  1. *Kruskal-Wallis one-way ANOVA
  2. Chi-square test
  3. ES, emphysema score; mean PAP, mean pulmonary artery pressure; UIP, usual interstitial pneumonia; NSIP, non-specific interstitial pneumonia; NS, not significant (P > 0.05).