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Table 1 mRNA Levels of extracellular matrix (ECM) molecules in cultured discoidin domain receptor 2 (DDR2)+/+ and DDR2-/- skin fibroblasts

From: Impaired dermal wound healing in discoidin domain receptor 2-deficient mice associated with defective extracellular matrix remodeling

mRNA DDR2+/+ DDR2-/- Expression when DDR2 is absent
Col I (α 1) 2.54 ± 0.04 1.34 ± 0.11 Down
Col VI (α 2) 0.31 ± 0.07 0.45 ± 0.05 Up
Col VIII (α 1) 0.56 ± 0.02 0.34 ± 0.05 Down
Syndecan1 1.01 ± 0.06 0.06 ± 0.10 Down
Fibrillin 1 0.95 ± 0.01 0.78 ± 0.02 Down
Fibronectin 0.17 ± 0.01 0.13 ± 0.04 NS
α2 0.92 ± 0.03 1.52 ± 0.03 Up
α3 0.67 ± 0.07 0.61 ± 0.04 NS
DDR1 0.94 ± 0.20 0.91 ± 0.38 NS
MMP2 0.94 ± 0.01 0.31 ± 0.08 Down
MMP9 ND ND ND
MMP10 0.57 ± 0.09 0.24 ± 0.03 Down
MMP13 1.34 ± 0.10 1.17 ± 0.09 NS
  1. Relative mRNA expression of ECM molecules regulated by DDR2 expression in DDR2+/+ and DDR2-/- skin fibroblasts. Gene expression was normalized to RPL13 mRNA expression. ND indicates mRNA was not detected. Results are expressed as means ± standard error of the mean (SEM) (n = 3). All P < 0.05 except for NS.
  2. MMP = matrix metalloproteinase; NS = not significantly different.