Figure 5
From: Cooperative interaction of CTGF and TGF-β in animal models of fibrotic disease
FG-3019 inhibits collagen deposition in lungs of bleomycin-treated mice. Pulmonary hydroxyproline (Hyp) content (μg/lung) of bleomycin-treated mice is expressed as the mean change from Hyp content of healthy control lungs (285 ± 8 μg/lung, mean ± SEM, n = 10). Mean Hyp content (μg/lung) increases for the 3, 10 and 30 mg/kg FG-3019 treatment groups (gray bars) were 27, 38 and 13% lower than for the bleomycin mice treated with vehicle (white bar), respectively. *P = 0.056 vs. bleomycin + vehicle (ANOVA, Fisher's LSD).