Figure 4
From: Cooperative interaction of CTGF and TGF-β in animal models of fibrotic disease
FG-3019 inhibits renal collagen deposition after unilateral ureteral obstruction (UUO). Hydroxyproline:proline (Hyp:Pro) ratios in renal tissues from UUO mice are expressed as the mean change above the mean Hyp:Pro ratio of unligated control kidneys (0.0446 ± 0.0005, n = 35). Mean renal Hyp:Pro ratio increases for the 10 and 30 mg/kg FG-3019 treatment groups (gray bars) were 20% and 15% lower than for the UUO kidneys of vehicle-treated controls (white bar), respectively. *P < 0.05 compared with UUO + vehicle (analysis of variance, Fisher's least significant difference).