Figure 3
From: Cooperative interaction of CTGF and TGF-β in animal models of fibrotic disease
Hepatic and renal fibrosis in mice receiving transforming growth factor (TGF)-β and connective tissue growth factor (CTGF) is ameliorated by FG-3019 treatment. (A, B) Liver and ( C, D) kidney of 21-day-old animals coadministered TGF-β2 and CTGF; animals were treated with either (A, C) vehicle or (B, D) FG-3019. All agents were administered daily for 20 days beginning one day after birth. Arrows indicate regions of robust capsular fibrosis inhibited by FG-3019 treatment. Representative images are shown (all haematoxylin and eosin, original magnification × 200).