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Table 1 Animal models for chronic pancreatitis according to the type of stimulus

From: Animal models for investigating chronic pancreatitis

Model Stimulus
Duct ligation model Pancreatic duct ligation
  Incomplete duct ligation
  Occlusion with tissue glue, acrylate, glass particles
Repetitive acute pancreatitis Serial caerulein injections
  Serial L-arginine injections
Alcohol feeding Lieber-DeCarli formula
Genetic models Wistar Bonn/Kobori (WBN/Kob) rats
  R122H transgenic mice
  SPINK3-deficient (SPINK3(-/-)) mice
  CFTR-deficient (cftrm1UNC) mice and CFTR(-/-) pigs
  Kif3a-deficient mice
  PERK-deficient (PERK(-/-)) mice
  Interleukin 1β transgenic mice (elastase sshIL-1β mice)
  1. CFTR = cystic fibrosis transmembrane conductance regulator; PERK = protein kinase R-like endoplasmic reticulum kinase.