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Table 1 Animal models for chronic pancreatitis according to the type of stimulus

From: Animal models for investigating chronic pancreatitis



Duct ligation model

Pancreatic duct ligation


Incomplete duct ligation


Occlusion with tissue glue, acrylate, glass particles

Repetitive acute pancreatitis

Serial caerulein injections


Serial L-arginine injections

Alcohol feeding

Lieber-DeCarli formula

Genetic models

Wistar Bonn/Kobori (WBN/Kob) rats


R122H transgenic mice


SPINK3-deficient (SPINK3(-/-)) mice


CFTR-deficient (cftrm1UNC) mice and CFTR(-/-) pigs


Kif3a-deficient mice


PERK-deficient (PERK(-/-)) mice


Interleukin 1β transgenic mice (elastase sshIL-1β mice)

  1. CFTR = cystic fibrosis transmembrane conductance regulator; PERK = protein kinase R-like endoplasmic reticulum kinase.