A genetic polymorphism in the CAV1 gene associates with the development of bronchiolitis obliterans syndrome after lung transplantation

Table 4 Baseline characteristics of BOS^pos and BOS^neg patients (BOS^neg matched and unmatched) and healthy controls and patients with idiopathic pulmonary fibrosis^a

Variables	BOS^pos	BOS^neg (matched)	BOS^neg (unmatched)	Controls	IPF
Total number	10	10	33	60	25
Gender, n
Male	3	4	18	30	18
Female	7	6	15	30	7
Mean age (± SD), years	45.2 ± 15.0	45.7 ± 13.1	48.2 ± 13.9	46.7 ± 11.3	64.7 ± 11.3
Diagnosis, n				NA	NA
COPD	3	3	8
CF	4	5	10
IPF	1	0	5
Sarcoidosis	1	0	2
α1 antitrypsin deficiency	1	1	3
Other	0	1	5
Type of graft, n				NA	NA
Bilateral	10	10	27
Unilateral	0	0	6
Survival, mean ± SD, months	33.6 ± 20.0	46.4 ± 9.5	51.6 ± 21.3	NA	NA
Mean BOS-free survival (± SD), months	19.3 ± 12.5	46.4 ± 9.5*	51.6 ± 21.3*	NA	NA
BOS grade at diagnosis, n		NA	NA	NA	NA
1	7
2	3
3	0
Histology		NA	NA	NA	NA
Biopsy, histological OB	4
Biopsy, no histological OB	2
No biopsy	4

^aBOS^pos, bronchiolitis obliterans syndrome-positive; BOS^neg, bronchiolitis obliterans syndrome-negative; * identical to survival; COPD, chronic obstructive pulmonary disease; CF, cystic fibrosis; IPF, idiopathic pulmonary fibrosis; OB, obliterative bronchiolitis; NA, not applicable; SD, standard deviation.

ISSN: 1755-1536