A genetic polymorphism in the CAV1 gene associates with the development of bronchiolitis obliterans syndrome after lung transplantation

Table 1 Baseline characteristics of BOS^pos and BOS^neg patients and healthy controls^a

Variables	BOS^pos	BOS^neg	Controls
Number of patients	20	90	422
Gender, n (%)
Male	9 (45%)	46 (51%)	228 (54%)
Female	11 (55%)	44 (49%)	194 (46%)
Mean age (± SD), years	53.4 ± 10.7	49.4 ± 12.7	48.2 ± 11.9
Diagnosis, n (%)			NA
COPD	7 (35%)	29 (32%)
CF	2 (10%)	24 (27%)
IPF	4 (20%)	13 (14%)
Sarcoidosis	2 (10%)	3 (3%)
α1 antitrypsin deficiency	5 (25%)	7 (8%)
Other	0	14 (16%)
Type of graft, n (%)			NA
Unilateral	4 (20%)	13 (14%)
Bilateral	16 (80%)	77 (86%)
Mean time to BOS (± SD), months	23.7 ± 15.2	NA	NA

^aBOS^pos, bronchiolitis obliterans syndrome-positive; BOS^neg, bronchiolitis obliterans syndrome-negative; COPD, chronic obstructive pulmonary disease; CF, cystic fibrosis; IPF, idiopathic pulmonary fibrosis; NA, not applicable; SD, standard deviation.

ISSN: 1755-1536