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Table 2 Fibronectin (FN)-binding integrins.

From: Plasma and cellular fibronectin: distinct and independent functions during tissue repair

FN receptor

Supports fibrillogenesis

Domain

References

α3β1

+

70-kDa

[63, 146]

α4β1

+

IIICS (V) CS1 region and EIIIA

[63, 146]

α5β1

+

FNIII9-10 (RGD)

[22, 60, 143, 144, 251]

α9β1

-

EIIIA

[65]

α8β1

-

FNIII10 (RGD)

[63, 64]

αvβ1

-

FNIII10 (RGD)

[63, 64]

αvβ3

+

FNIII10 (RGD) or possibly 70-kDa

[139, 143, 144]

αvβ6

+

FNIII10 (RGD)

[63]

αIIbβ3

+

FNIII9-10 (RGD)

[38, 63, 145, 252]

  1. + = Has been reported to be involved in FN fibrillogenesis.
  2. - = Has been reported to be involved in adhesion to FN but not fibrillogenesis.
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Fibrogenesis & Tissue Repair

ISSN: 1755-1536

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