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Table 1 Cellular fibronectin (FN) isoforms reported during physiological and pathological conditions

From: Plasma and cellular fibronectin: distinct and independent functions during tissue repair

FN isoform Characteristics Ref.
Physiological wound healing   
EIIIA Expressed in tubular basement membrane by endothelium in rat model of acute renal failure; involved in regeneration of proximal tubules [237]
  Increased expression by alveolar septal cells, albeolar macrophages and endothelial cells upon acute hyperoxic lung injury [238]
  Absence results in abnormal wound healing in EIIIA-/- mice [90]
  Expressed in rat model of liver injury by sinusoidal endothelial cells [98]
EIIIB Increased levels in blood plasma after acute major trauma [18]
  Increased expression by chondrocytes in muscularized arteries upon acute hyperoxic lung injury [238]
EIIIA and EIIIB Observed in granulation tissue by 7 days; EIIIB+ levels remain increased even after 14 days; EIIIA+ found around arterioles in connective tissue adjacent to the wound after 4 days [95]
  Deposited in basement membrane zone of keratectomy wound models of corneal injury in rats [239]
  Detected in ulcerated gastric tissue in rat models [240]
EIIIA, EIIIB and V All isoforms upregulated during rat corneal wound healing [241]
Pathological conditions   
Fibrosis   
EIIIA Idiopathic pulmonary fibrotic fibroblasts isolated from patients express higher levels of EIIIA+FN [201]
  Involved in lung fibrogenesis in rat models of pulmonary fibrosis [201]
  Highly expressed in mesangium and interstitium in rat glioblastoma multiforme and Habu snake venom models of renal fibrosis [202]
  Increased expression in acute and chronic cutaneous graft-versus-host disease [200]
  Increased in fibrotic periglomerular regions and areas of interstitial fibrosis [26]
  Increased expression in human hepatic fibrosis [242]
  Can induce the conversion of lipocytes to myofibroblasts; may play a role in hepatic fibrogenesis [98]
EIIIB Increased in obsolescent glomeruli [26]
EIIIA and EIIIB Increased in glomerulosclerotic lesions and fibrous crescents [26]
Tumorigenesis   
EIIIA Increased expression in hepatocellular carcinomas [242]
EIIIB Increased expression in interstitium and vascular intima of many primary human tumors including meningioma [243]
  Expressed around neovasculature and stroma of many malignant head and neck tumors [244]
  Detected around tumor stroma, tumor vasculature and in tissue adjacent to the invasion front of oral squamous cell carcinomas [245]
  Detected in the stroma, in the cytoplasm of tumor cells and endothelial cells in the neovasculature of head and neck squamous cell carcinomas [246]
EIIIA and EIIIB Expressed in tumor blood vessels in mouse model of pancreatic tumorigenesis [247]
  Present around the blood vessels of intratumoral microvessels in breast carcinomas. [248]
Other   
EIIIA Increased plasma levels in synovial fluid of rheumatoid arthritic joints [249]
EIIIA, EIIIB and V Increased expression in rat model of hypertension, especially of EIIIA+ form after 21 d [250]