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Table 1 Body weight, liver-function test results and serum electrolyte values in the rats of the study

From: Circulating CO3-610, a degradation product of collagen III, closely reflects liver collagen and portal pressure in rats with fibrosis

 

Control (n = 20)

Fibrosis

  

Mild/moderate (n = 33)

Severe (n = 15)

Cirrhosis (n = 20)

Body weight, g

399 ± 8

369 ± 6

367 ± 9

383 ± 9

ALT, U/L a

12.8 ± 1

88.6 ± 31.8

138.1 ± 71*

119.6 ± 31.5***

AST, U/L b

117 ± 23

219 ± 27

355 ± 92**

512 ± 69***

LDH, U/L c

1093 ± 106

1455 ± 154*

1386 ± 134*

917 ± 112

Albumin, g/l

36.1 ± 0.5

34.9 ± 0.5

33.3 ± 1.0

29.0 ± 0.8***

Serum Na + , mEq/l

142 ± 1.6

142.6 ± 0.5

142.9 ± 0.4

141.5 ± 0.5*

Serum K + , mEq/l

5.7 ± 0.2

6.0 ± 0.1

5.7 ± 0.1

4.8 ± 0.2

Serum osmolality, mOsm/Kg

292 ± 6

294 ± 3

291 ± 3

289 ± 1

  1. a Alanine aminotransferase.
  2. bAspartate aminotransferase.
  3. cLactate dehydrogenase.
  4. *P < 0.05; **P < 0.01 and ***P < 0.001 compared with control rats (one-way ANOVA with Newman-Keuls post hoc test and Kruskal--Wallis test with Dunn post hoc tests as appropriate).