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Table 1 Body weight, liver-function test results and serum electrolyte values in the rats of the study

From: Circulating CO3-610, a degradation product of collagen III, closely reflects liver collagen and portal pressure in rats with fibrosis

  Control (n = 20) Fibrosis
   Mild/moderate (n = 33) Severe (n = 15) Cirrhosis (n = 20)
Body weight, g 399 ± 8 369 ± 6 367 ± 9 383 ± 9
ALT, U/L a 12.8 ± 1 88.6 ± 31.8 138.1 ± 71* 119.6 ± 31.5***
AST, U/L b 117 ± 23 219 ± 27 355 ± 92** 512 ± 69***
LDH, U/L c 1093 ± 106 1455 ± 154* 1386 ± 134* 917 ± 112
Albumin, g/l 36.1 ± 0.5 34.9 ± 0.5 33.3 ± 1.0 29.0 ± 0.8***
Serum Na + , mEq/l 142 ± 1.6 142.6 ± 0.5 142.9 ± 0.4 141.5 ± 0.5*
Serum K + , mEq/l 5.7 ± 0.2 6.0 ± 0.1 5.7 ± 0.1 4.8 ± 0.2
Serum osmolality, mOsm/Kg 292 ± 6 294 ± 3 291 ± 3 289 ± 1
  1. a Alanine aminotransferase.
  2. bAspartate aminotransferase.
  3. cLactate dehydrogenase.
  4. *P < 0.05; **P < 0.01 and ***P < 0.001 compared with control rats (one-way ANOVA with Newman-Keuls post hoc test and Kruskal--Wallis test with Dunn post hoc tests as appropriate).