CO3-610 serum levels in experimental fibrosis induced by chronic administration of carbon tetrachloride in rats. (A) Serum concentrations of CO3-610 in control (untreated) rats (n = 20), and rates with mild/moderate fibrosis (n = 33), severe fibrosis (n = 15) and cirrhotic (n = 20). The box contains the values between the 25th and 75th percentiles, and the horizontal line is the median. Whiskers show the range of the data. Significance is denoted versus the control animals. (B) Correlation of CO3-610 serum levels with histological quantification of liver fibrosis in all CCl4-treated rats.