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Figure 8 | Fibrogenesis & Tissue Repair

Figure 8

From: TLR9-induced interferon β is associated with protection from gammaherpesvirus-induced exacerbation of lung fibrosis

Figure 8

Infection by gamma herpesvirus 68 (γHV68) limits Balb/c, but not TLR-9-/- fibroblast proliferation. Fibroblasts from (A) Balb/c and (B) TLR-9-/- mice were infected in vitro with 0.01 PFU γHV68, and proliferation was measured 24 hours later by 3H-thymidine incorporation (n = 6 samples/group). The results are presented as the percentage proliferation compared with the highest value in the uninfected fibroblasts. In the wild-type mice, infection resulted in a 35.2% reduction in proliferation (67.5% ± 8.9% versus 32.3% ± 2.7%, P = 0.003), whereas in the TLR-9-/- mice, infection did not result in a significant change in proliferation (83.2% ± 5.0% versus 79.8% ± 3.9%, P = 0.56).

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