Figure 7
Gamma herpesvirus 68 (γHV68) infection induces interferon (IFN)-β, which in turn limits fibroblast proliferation. (A) Fibroblasts from Balb/c mice were infected with 0, 0.001, 0.01 and 0.1 MOI γHV68 in vitro, and levels of IFN-β in the supernatant were measured 24 hours later (n = 6/group). (B) Fibroblasts from (left) Balb/c or (right) TLR-9-/- mice were cultured at 5000 cells/well in the presence of increasing concentrations of IFN-β. IFN-β limited proliferation of fibroblasts at all doses tested (n = 6/group).