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Table 2 Evaluation of immunohistochemical staininga

From: Elevated transforming growth factor β and mitogen-activated protein kinase pathways mediate fibrotic traits of Dupuytren's disease fibroblasts

Patients TGF-β3 P-Smad2 α-SMA
Control 1 + ++ -
Control 2 ++ ++ -
Control 3 + ++ -
Control 4 + - -
Dupuytren 1 +++ ++ ++
Dupuytren 2 +++ +++ +++
Dupuytren 3 +++ +++ +++
Dupuytren 4 +++ ++ +++
  1. aEvaluation of immunohistochemical staining was performed on four control and four Dupuytren tissue samples. Positivity was graded on a scale from (-) to (+++), with (-) representing no staining, (+) representing weak staining, (++) representing moderate staining and (+++) representing strong staining. Staining in blood vessels was not included. The scoring was performed on unlabelled samples by a pathologist not involved in the study. Representative images are shown in Figure 1C.