aEvaluation of immunohistochemical staining was performed on four control and four Dupuytren tissue samples. Positivity was graded on a scale from (-) to (+++), with (-) representing no staining, (+) representing weak staining, (++) representing moderate staining and (+++) representing strong staining. Staining in blood vessels was not included. The scoring was performed on unlabelled samples by a pathologist not involved in the study. Representative images are shown in Figure 1C.