Figure 5
From: Immune response CC chemokines CCL2 and CCL5 are associated with pulmonary sarcoidosis
Immunohistochemistry for CC chemokine receptor type 2 (CCR2) on lung biopsy tissues. Representative immunohistochemistry for CCR2 (a-c) and isotype control antibody (d) on lung biopsy tissue from stages II pulmonary sarcoidosis without alveolitis and on empiric therapy. CCR2 protein expression was found in epithelioid histiocytes and multinucleated giant cells forming non-necrotizing granulomas, as well as from surrounding alveolar macrophages and other infiltrating mononuclear cells. Panels were photographed at 50 × (a, d), 100 × (b), and 200 × (c) original magnification.