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Table 2 Average fold differences in steady-state mRNA levels compared with non-stimulated tenocytes, at 6 h and 24 h of activation, for cell cycle-related genes.

From: Interleukins 4 and 13 modulate gene expression and promote proliferation of primary human tenocytes

mRNA

6 h

 

24 h

 

IL-4

IL-13

IL-4

IL-13

CDK6

2.22

2.26

3.08

2.62

CDKN2B

0.31

0.32

0.22

0.28

CDKN1A

2.21

2.25

--

--

Nibrin

2.97

3.04

--

--

Cyclin B1

--

--

0.35

0.33

Cyclin B2

--

--

0.23

0.21

Cyclin E1

--

--

3.95

3.97

CDK1

--

--

0.17

0.14

CDK5

--

--

6.35

2.1

CDKN3

--

--

0.16

0.19

Cdc20

--

--

0.24

0.27

Cdc21

--

--

2.6

2

Cdc46

--

--

2.78

1.91

GADD45A

--

--

0.37

0.46

HUS1a

--

--

2.72

1.9

Ki-67b

--

--

0.15

0.2

Dp-1c

--

--

2.05

3.64

p53d

--

--

2.63

3.17

  1. For clarity, the standard deviations are not shown, but the variability within each group did not exceed 0.25 cycles of PCR amplification.
  2. -- = difference was > 0.5 but < 2.0; Cdc = cell division cycle; CDK = cyclin-dependent kinase; CDKN = cyclin-dependent kinase inhibitor; GADD45A = growth arrest and DNA-damage-inducible alpha.
  3. aCheckpoint homolog.
  4. bProliferation-related antigen.
  5. cTranscription factor.
  6. dTumor suppressor protein.