TY - JOUR AU - Hinz, B. AU - Phan, S. H. AU - Thannickal, V. J. AU - Galli, A. AU - Bochaton-Piallat, M. L. AU - Gabbiani, G. PY - 2007 DA - 2007// TI - The myofibroblast: one function, multiple origins JO - Am J Pathol VL - 170 UR - https://doi.org/10.2353/ajpath.2007.070112 DO - 10.2353/ajpath.2007.070112 ID - Hinz2007 ER - TY - JOUR AU - Chen, Y. AU - Shiwen, X. AU - van Beek, J. AU - Kennedy, L. AU - McLeod, M. AU - Renzoni, E. A. AU - Bou-Gharios, G. AU - Wilcox-Adelman, S. AU - Goetinck, P. F. AU - Eastwood, M. AU - Black, C. M. AU - Abraham, D. J. AU - Leask, A. PY - 2005 DA - 2005// TI - Matrix contraction by dermal fibroblasts requires TGFbeta/ALK5, heparan sulfate containing proteoglycans and MEK/ERK: Insights into pathological scarring in chronic fibrotic disease JO - Am J Pathol VL - 167 UR - https://doi.org/10.1016/S0002-9440(10)61252-7 DO - 10.1016/S0002-9440(10)61252-7 ID - Chen2005 ER - TY - JOUR AU - Denton, C. P. AU - Abraham, D. J. PY - 2001 DA - 2001// TI - Transforming growth factor-beta and connective tissue growth factor: key cytokines in scleroderma pathogenesis JO - Curr Opin Rheumatol VL - 13 UR - https://doi.org/10.1097/00002281-200111000-00010 DO - 10.1097/00002281-200111000-00010 ID - Denton2001 ER - TY - JOUR AU - Kapoun, A. M. AU - Gaspar, N. J. AU - Wang, Y. AU - Damm, D. AU - Liu, Y. W. AU - O'young, G. AU - Quon, D. AU - Lam, A. AU - Munson, K. AU - Tran, T. T. AU - Ma, J. Y. AU - Murphy, A. AU - Dugar, S. AU - Chakravarty, S. AU - Protter, A. A. AU - Wen, F. Q. AU - Liu, X. AU - Rennard, S. I. AU - Higgins, L. S. PY - 2006 DA - 2006// TI - Transforming growth factor-beta receptor type 1 (TGFbetaRI) kinase activity but not p38 activation is required for TGFbetaRI-induced myofibroblast differentiation and profibrotic gene expression JO - Mol Pharmacol VL - 70 UR - https://doi.org/10.1124/mol.105.021600 DO - 10.1124/mol.105.021600 ID - Kapoun2006 ER - TY - JOUR AU - Chen, Y. AU - Shi-wen, X. AU - Eastwood, M. AU - Black, C. M. AU - Denton, C. P. AU - Leask, A. AU - Abraham, D. J. PY - 2006 DA - 2006// TI - Contribution of activin receptor-like kinase 5 (transforming growth factor beta receptor type I) signaling to the fibrotic phenotype of scleroderma fibroblasts JO - Arthritis Rheum VL - 54 UR - https://doi.org/10.1002/art.21725 DO - 10.1002/art.21725 ID - Chen2006 ER - TY - JOUR AU - Ishida, W. AU - Mori, Y. AU - Lakos, G. AU - Sun, L. AU - Shan, F. AU - Bowes, S. AU - Josiah, S. AU - Lee, W. C. AU - Singh, J. AU - Ling, L. E. AU - Varga, J. PY - 2006 DA - 2006// TI - Intracellular TGF-beta receptor blockade abrogates Smad-dependent fibroblast activation in vitro and in vivo JO - J Invest Dermatol VL - 126 UR - https://doi.org/10.1038/sj.jid.5700303 DO - 10.1038/sj.jid.5700303 ID - Ishida2006 ER - TY - JOUR AU - Holmes, A. AU - Abraham, D. J. AU - Sa, S. AU - Shiwen, X. AU - Black, C. M. AU - Leask, A. PY - 2001 DA - 2001// TI - CTGF and SMADs, maintenance of scleroderma phenotype is independent of SMAD signaling JO - J Biol Chem VL - 276 UR - https://doi.org/10.1074/jbc.M010149200 DO - 10.1074/jbc.M010149200 ID - Holmes2001 ER - TY - JOUR AU - Mori, Y. AU - Chen, S. J. AU - Varga, J. PY - 2003 DA - 2003// TI - Expression and regulation of intracellular SMAD signaling in scleroderma skin fibroblasts JO - Arthritis Rheum VL - 48 UR - https://doi.org/10.1002/art.11157 DO - 10.1002/art.11157 ID - Mori2003 ER - TY - JOUR AU - Pannu, J. AU - Nakerakanti, S. AU - Smith, E. AU - ten Dijke, P. AU - Trojanowska, M. PY - 2007 DA - 2007// TI - Transforming growth factor-beta receptor type I-dependent fibrogenic gene program is mediated via activation of Smad1 and ERK1/2 pathways JO - J Biol Chem VL - 282 UR - https://doi.org/10.1074/jbc.M611742200 DO - 10.1074/jbc.M611742200 ID - Pannu2007 ER - TY - JOUR AU - Pannu, J. AU - Gore-Hyer, E. AU - Yamanaka, M. AU - Smith, E. A. AU - Rubinchik, S. AU - Dong, J. Y. AU - Jablonska, S. AU - Blaszczyk, M. AU - Trojanowska, M. PY - 2004 DA - 2004// TI - An increased transforming growth factor beta receptor type I:type II ratio contributes to elevated collagen protein synthesis that is resistant to inhibition via a kinase-deficient transforming growth factor beta receptor type II in scleroderma JO - Arthritis Rheum VL - 50 UR - https://doi.org/10.1002/art.20225 DO - 10.1002/art.20225 ID - Pannu2004 ER - TY - JOUR AU - Pannu, J. AU - Gardner, H. AU - Shearstone, J. R. AU - Smith, E. AU - Trojanowska, M. PY - 2006 DA - 2006// TI - Increased levels of transforming growth factor beta receptor type I and up-regulation of matrix gene program: A model of scleroderma JO - Arthritis Rheum VL - 54 UR - https://doi.org/10.1002/art.22063 DO - 10.1002/art.22063 ID - Pannu2006 ER - TY - JOUR AU - Leask, A. PY - 2008 DA - 2008// TI - Targeting the TGFβ, endothelin-1 and CCN2 axis to combat fibrosis in scleroderma JO - Cell Signal VL - 20 UR - https://doi.org/10.1016/j.cellsig.2008.01.006 DO - 10.1016/j.cellsig.2008.01.006 ID - Leask2008 ER - TY - JOUR AU - Trojanowska, M. PY - 2009 DA - 2009// TI - Noncanonical transforming growth factor beta signaling in scleroderma fibrosis JO - Curr Opin Rheumatol VL - 21 UR - https://doi.org/10.1097/BOR.0b013e32833038ce DO - 10.1097/BOR.0b013e32833038ce ID - Trojanowska2009 ER - TY - JOUR AU - Shi-wen, X. AU - Parapuram, S. K. AU - Pala, D. AU - Chen, Y. AU - Carter, D. AU - Eastwood, M. AU - Abraham, D. J. AU - Leask, A. PY - 2009 DA - 2009// TI - TGFβ induced α-smooth muscle actin expression and extracellular matrix contraction in fibroblasts requires TAK1 JO - Arthritis Rheum VL - 60 UR - https://doi.org/10.1002/art.24223 DO - 10.1002/art.24223 ID - Shi-wen2009 ER - TY - JOUR AU - Thannickal, V. J. AU - Lee, D. Y. AU - White, E. S. AU - Cui, Z. AU - Larios, J. M. AU - Chacon, R. AU - Horowitz, J. C. AU - Day, R. M. AU - Thomas, P. E. PY - 2003 DA - 2003// TI - Myofibroblast differentiation by transforming growth factor-beta1 is dependent on cell adhesion and integrin signaling via focal adhesion kinase JO - J Biol Chem VL - 278 UR - https://doi.org/10.1074/jbc.M208544200 DO - 10.1074/jbc.M208544200 ID - Thannickal2003 ER - TY - JOUR AU - Leask, A. AU - Holmes, A. AU - Black, C. M. AU - Abraham, D. J. PY - 2003 DA - 2003// TI - Connective tissue growth factor gene regulation Requirements for its induction by transforming growth factor-beta 2 in fibroblasts JO - J Biol Chem VL - 278 UR - https://doi.org/10.1074/jbc.M210366200 DO - 10.1074/jbc.M210366200 ID - Leask2003 ER - TY - JOUR AU - Li, F. AU - Zeng, B. AU - Chai, Y. AU - Cai, P. AU - Fan, C. AU - Cheng, T. PY - 2009 DA - 2009// TI - The linker region of Smad2 mediates TGF-beta-dependent ERK2-induced collagen synthesis JO - Biochem Biophys Res Commun VL - 386 UR - https://doi.org/10.1016/j.bbrc.2009.05.084 DO - 10.1016/j.bbrc.2009.05.084 ID - Li2009 ER - TY - JOUR AU - Shi-wen, X. AU - Rodrigues-Pascua, F. AU - Lamas, S. AU - Holmes, A. AU - Howat, S. AU - Pearson, J. D. AU - Dashwood, M. R. AU - du Bois, R. M. AU - Denton, C. P. AU - Black, C. M. AU - Abraham, D. J. AU - Leask, A. PY - 2006 DA - 2006// TI - Constitutive ALK5-indepenent JNK activation contributes to endothelin-1 over-expression in pulmonary fibrosis JO - Mol Cell Biol VL - 26 UR - https://doi.org/10.1128/MCB.00625-06 DO - 10.1128/MCB.00625-06 ID - Shi-wen2006 ER - TY - JOUR AU - Shi-Wen, X. AU - Chen, Y. AU - Denton, C. P. AU - Eastwood, M. AU - Renzoni, E. A. AU - Bou-Gharios, G. AU - Pearson, J. D. AU - Dashwood, M. AU - du Bois, R. M. AU - Black, C. M. AU - Leask, A. AU - Abraham, D. J. PY - 2004 DA - 2004// TI - Endothelin-1 promotes myofibroblast induction through the ETA receptor via a rac/phosphoinositide 3-kinase/Akt-dependent pathway and is essential for the enhanced contractile phenotype of fibrotic fibroblasts JO - Mol Biol Cel VL - 15 UR - https://doi.org/10.1091/mbc.E03-12-0902 DO - 10.1091/mbc.E03-12-0902 ID - Shi-Wen2004 ER - TY - JOUR AU - Xu, S. W. AU - Howat, S. L. AU - Renzoni, E. A. AU - Holmes, A. AU - Pearson, J. D. AU - Dashwood, M. R. AU - Bou-Gharios, G. AU - Denton, C. P. AU - du Bois, R. M. AU - Black, C. M. AU - Leask, A. AU - Abraham, D. J. PY - 2004 DA - 2004// TI - Endothelin-1 induces expression of matrix-associated genes in lung fibroblasts through MEK/ERK JO - J Biol Chem VL - 279 UR - https://doi.org/10.1074/jbc.M311430200 DO - 10.1074/jbc.M311430200 ID - Xu2004 ER - TY - JOUR AU - Shi-wen, X. AU - Kennedy, L. AU - Renzoni, E. AU - du Bois, R. AU - Denton, C. AU - Black, C. AU - Abraham, D. AU - Leask, A. PY - 2007 DA - 2007// TI - Endothelin-1 is a downstream mediator of TGFβ in fibroblasts JO - Arthritis Rheum VL - 56 UR - https://doi.org/10.1002/art.23134 DO - 10.1002/art.23134 ID - Shi-wen2007 ER - TY - JOUR AU - Park, S. H. AU - Saleh, D. AU - Giaid, A. AU - Michel, R. P. PY - 1997 DA - 1997// TI - Increased endothelin-1 in bleomycin-induced pulmonary fibrosis and the effect of an endothelin receptor antagonist JO - Am J Respir Crit Care Med VL - 156 UR - https://doi.org/10.1164/ajrccm.156.2.9607123 DO - 10.1164/ajrccm.156.2.9607123 ID - Park1997 ER - TY - JOUR AU - Lagares, D. AU - García-Fernández, R. A. AU - Jiménez, C. L. AU - Magán-Marchal, N. AU - Busnadiego, O. AU - Lamas, S. AU - Rodríguez-Pascual, F. PY - 2010 DA - 2010// TI - Endothelin 1 contributes to the effect of transforming growth factor beta1 on wound repair and skin fibrosis JO - Arthritis Rheum VL - 62 UR - https://doi.org/10.1002/art.27307 DO - 10.1002/art.27307 ID - Lagares2010 ER - TY - JOUR AU - Shephard, P. AU - Hinz, B. AU - Smola-Hess, S. AU - Meister, J. J. AU - Krieg, T. AU - Smola, H. PY - 2004 DA - 2004// TI - Dissecting the roles of endothelin, TGF-beta and GM-CSF on myofibroblast differentiation by keratinocytes JO - Thromb Haemost VL - 92 ID - Shephard2004 ER - TY - CHAP AU - Kuhn, A. AU - Haust, M. AU - Ruland, V. AU - Weber, R. AU - Verde, P. AU - Felder, G. AU - Ohmann, C. AU - Gensch, K. AU - Ruzicka, T. PY - 2010 DA - 2010// TI - Effect of bosentan on skin fibrosis in patients with systemic sclerosis: a prospective, open-label, non-comparative trial BT - Rheumatology (Oxford) ID - Kuhn2010 ER - TY - JOUR AU - Takehara, K. PY - 2003 DA - 2003// TI - Hypothesis: pathogenesis of systemic sclerosis JO - J Rheumatol VL - 30 ID - Takehara2003 ER - TY - JOUR AU - Chen, C. C. AU - Lau, L. F. PY - 2009 DA - 2009// TI - Functions and mechanisms of action of CCN matricellular proteins JO - Int J Biochem Cell Biol VL - 41 UR - https://doi.org/10.1016/j.biocel.2008.07.025 DO - 10.1016/j.biocel.2008.07.025 ID - Chen2009 ER - TY - JOUR AU - Mori, T. AU - Kawara, S. AU - Shinozaki, M. AU - Hayashi, N. AU - Kakinuma, T. AU - Igarashi, A. AU - Takigawa, M. AU - Nakanishi, T. AU - Takehara, K. PY - 1999 DA - 1999// TI - Role and interaction of connective tissue growth factor with transforming growth factor-beta in persistent fibrosis: a mouse fibrosis model JO - J Cell Physiol VL - 181 UR - https://doi.org/3.0.CO;2-K DO - 3.0.CO;2-K ID - Mori1999 ER - TY - JOUR AU - Bonniaud, P. AU - Martin, G. AU - Margetts, P. J. AU - Ask, K. AU - Robertson, J. AU - Gauldie, J. AU - Kolb, M. PY - 2004 DA - 2004// TI - Connective tissue growth factor is crucial to inducing a profibrotic environment in 'fibrosis-resistant' BALB/c mouse lungs JO - Am J Respir Cell Mol Biol VL - 31 UR - https://doi.org/10.1165/rcmb.2004-0158OC DO - 10.1165/rcmb.2004-0158OC ID - Bonniaud2004 ER - TY - JOUR AU - Sonnylal, S. AU - Shi-Wen, X. AU - Leoni, P. AU - Naff, K. AU - Van Pelt, C. AU - Nakamura, H. AU - Leask, A. AU - Abraham, D. AU - Bou-Gharios, G. AU - de Crombrugghe, B. PY - 2010 DA - 2010// TI - Selective expression of connective tissue growth factor in fibroblasts in vivo promotes systemic tissue fibrosis JO - Arthritis Rheum VL - 62 UR - https://doi.org/10.1002/art.27382 DO - 10.1002/art.27382 ID - Sonnylal2010 ER - TY - JOUR AU - Shi-wen, X. AU - Stanton, L. AU - Kennedy, L. AU - Pala, D. AU - Chen, Y. AU - Howat, S. L. AU - Renzoni, E. A. AU - Carter, D. E. AU - Bou-Gharios, G. AU - Stratton, R. J. AU - Pearson, J. D. AU - Beier, F. AU - Lyons, K. M. AU - Black, C. M. AU - Abraham, D. J. AU - Leask, A. PY - 2006 DA - 2006// TI - CCN2 is necessary for adhesive responses to TGFβ1 in embryonic fibroblasts JO - J Biol Chem VL - 281 UR - https://doi.org/10.1074/jbc.M511343200 DO - 10.1074/jbc.M511343200 ID - Shi-wen2006 ER - TY - JOUR AU - Kennedy, L. AU - Liu, S. AU - Shi-wen, X. AU - Carter, D. AU - Lyons, K. AU - Black, C. M. AU - Abraham, D. J. AU - Leask, A. PY - 2007 DA - 2007// TI - CCN2 is essential for fibroblast function JO - Expl Cell Res VL - 313 UR - https://doi.org/10.1016/j.yexcr.2006.12.006 DO - 10.1016/j.yexcr.2006.12.006 ID - Kennedy2007 ER - TY - JOUR AU - Ponticos, M. AU - Holmes, A. M. AU - Shiwen, X. AU - Leoni, P. l. AU - Khan, K. AU - Rajkumar, V. S. AU - Hoyles, R. K. AU - Bou-Gharios, G. AU - Black, C. M. AU - Denton, C. P. AU - Abraham, D. J. AU - Leask, A. AU - Lindahl, G. E. PY - 2009 DA - 2009// TI - Pivotal role of connective tissue growth factor in lung fibrosis: MAPK-dependent transcriptional activation of type I collagen JO - Arthritis Rheum VL - 60 UR - https://doi.org/10.1002/art.24620 DO - 10.1002/art.24620 ID - Ponticos2009 ER - TY - JOUR AU - Bonner, J. C. PY - 2004 DA - 2004// TI - Regulation of PDGF and its receptors in fibrotic diseases JO - Cytokine Growth Factor Rev VL - 15 UR - https://doi.org/10.1016/j.cytogfr.2004.03.006 DO - 10.1016/j.cytogfr.2004.03.006 ID - Bonner2004 ER - TY - JOUR AU - Rhee, S. AU - Grinnell, F. PY - 2006 DA - 2006// TI - P21-activated kinase 1: convergence point in PDGF- and LPA-stimulated collagen matrix contraction by human fibroblasts JO - J Cell Biol VL - 172 UR - https://doi.org/10.1083/jcb.200505175 DO - 10.1083/jcb.200505175 ID - Rhee2006 ER - TY - JOUR AU - Ludwicka, A. AU - Ohba, T. AU - Trojanowska, M. AU - Yamakage, A. AU - Strange, C. AU - Smith, E. A. AU - Leroy, E. C. AU - Sutherland, S. AU - Silver, R. M. PY - 1995 DA - 1995// TI - Elevated levels of platelet derived growth factor and transforming growth factor-beta 1 in bronchoalveolar lavage fluid from patients with scleroderma JO - J Rheumatol VL - 22 ID - Ludwicka1995 ER - TY - JOUR AU - Klareskog, L. AU - Gustafsson, R. AU - Scheynius, A. AU - Hällgren, R. PY - 1990 DA - 1990// TI - Increased expression of platelet-derived growth factor type B receptors in the skin of patients with systemic sclerosis JO - Arthritis Rheum VL - 33 UR - https://doi.org/10.1002/art.1780331011 DO - 10.1002/art.1780331011 ID - Klareskog1990 ER - TY - JOUR AU - Zheng, X. Y. AU - Zhang, J. Z. AU - Tu, P. AU - Ma, S. Q. PY - 1998 DA - 1998// TI - Expression of platelet-derived growth factor B-chain and platelet-derived growth factor beta-receptor in fibroblasts of scleroderma JO - J Dermatol Sci VL - 18 UR - https://doi.org/10.1016/S0923-1811(98)00027-9 DO - 10.1016/S0923-1811(98)00027-9 ID - Zheng1998 ER - TY - JOUR AU - Baroni, S. S. AU - Santillo, M. AU - Bevilacqua, F. AU - Luchetti, M. AU - Spadoni, T. AU - Mancini, M. AU - Fraticelli, P. AU - Sambo, P. AU - Funaro, A. AU - Kazlauskas, A. AU - Avvedimento, E. V. AU - Gabrielli, A. PY - 2006 DA - 2006// TI - Stimulatory autoantibodies to the PDGF receptor in systemic sclerosis JO - N Engl J Med VL - 354 UR - https://doi.org/10.1056/NEJMoa052955 DO - 10.1056/NEJMoa052955 ID - Baroni2006 ER - TY - JOUR AU - Rajkumar, V. S. AU - Shiwen, X. AU - Bostrom, M. AU - Leoni, P. AU - Muddle, J. AU - Ivarsson, M. AU - Gerdin, B. AU - Denton, C. P. AU - Bou-Gharios, G. AU - Black, C. M. AU - Abraham, D. J. PY - 2006 DA - 2006// TI - Platelet-derived growth factor-beta receptor activation is essential for fibroblast and pericyte recruitment during cutaneous wound healing JO - Am J Pathol VL - 169 UR - https://doi.org/10.2353/ajpath.2006.060196 DO - 10.2353/ajpath.2006.060196 ID - Rajkumar2006 ER - TY - JOUR AU - Kapoor, M. AU - Liu, S. AU - Huh, K. AU - Parapuram, S. AU - Kennedy, L. AU - Leask, A. PY - 2008 DA - 2008// TI - Connective tissue growth factor promoter activity in normal and wounded skin JO - Fibrogenesis Tissue Repair VL - 1 UR - https://doi.org/10.1186/1755-1536-1-3 DO - 10.1186/1755-1536-1-3 ID - Kapoor2008 ER - TY - JOUR AU - Liu, S. AU - Taghavi, R. AU - Leask, A. PY - 2010 DA - 2010// TI - Connective tissue growth factor is induced in bleomycin-induced skin scleroderma JO - J Cell Commun Signal VL - 4 UR - https://doi.org/10.1007/s12079-009-0081-3 DO - 10.1007/s12079-009-0081-3 ID - Liu2010 ER - TY - JOUR AU - Akhmetshina, A. AU - Dees, C. AU - Pileckyte, M. AU - Maurer, B. AU - Axmann, R. AU - Jüngel, A. AU - Zwerina, J. AU - Gay, S. AU - Schett, G. AU - Distler, O. AU - Distler, J. H. PY - 2008 DA - 2008// TI - Dual inhibition of c-abl and PDGF receptor signaling by dasatinib and nilotinib for the treatment of dermal fibrosis JO - FASEB J VL - 22 UR - https://doi.org/10.1096/fj.07-105627 DO - 10.1096/fj.07-105627 ID - Akhmetshina2008 ER - TY - JOUR AU - Bhattacharyya, S. AU - Ishida, W. AU - Wu, M. AU - Wilkes, M. AU - Mori, Y. AU - Hinchcliff, M. AU - Leof, E. AU - Varga, J. PY - 2009 DA - 2009// TI - A non-Smad mechanism of fibroblast activation by transforming growth factor-beta via c-Abl and Egr-1: selective modulation by imatinib mesylate JO - Oncogene VL - 28 UR - https://doi.org/10.1038/onc.2008.479 DO - 10.1038/onc.2008.479 ID - Bhattacharyya2009 ER - TY - JOUR AU - Pannu, J. AU - Asano, Y. AU - Nakerakanti, S. AU - Smith, E. AU - Jablonska, S. AU - Blaszczyk, M. AU - ten Dijke, P. AU - Trojanowska, M. PY - 2008 DA - 2008// TI - Smad1 pathway is activated in systemic sclerosis fibroblasts and is targeted by imatinib mesylate JO - Arthritis Rheum VL - 58 UR - https://doi.org/10.1002/art.23698 DO - 10.1002/art.23698 ID - Pannu2008 ER - TY - JOUR AU - Rajkumar, V. S. AU - Sundberg, C. AU - Abraham, D. J. AU - Rubin, K. AU - Black, C. M. PY - 1999 DA - 1999// TI - Activation of microvascular pericytes in autoimmune Raynaud's phenomenon and systemic sclerosis JO - Arthritis Rheum VL - 42 UR - https://doi.org/3.0.CO;2-1 DO - 3.0.CO;2-1 ID - Rajkumar1999 ER -