Figure 2
From: Cell-matrix interactions in dermal repair and scarring
Formation of myofibroblasts and their effects on extracellular matrix (ECM) homeostasis. Myofibroblasts may arise from various cellular sources. Their differentiation and activity are modulated by the surrounding ECM, growth factor activity and mechanical tension. Myofibroblasts affect connective tissue homeostasis by upregulated production of ECM proteins, fibrogenic mediators and protease inhibitors.