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Figure 1 | Fibrogenesis & Tissue Repair

Figure 1

From: Cell-matrix interactions in dermal repair and scarring

Figure 1

Integrin signaling. Activated integrins bind to extracellular matirix (ECM)ligands and signal via phosphorylation of intracellular linker proteins or lipid second messengers and small GTPases, eliciting reorganization of the cytoskeleton, changes in gene expression and modulation of many cellular responses. AKT, protein kinase B; ERK, extracellular signal-regulated kinase; JNK, Jun N-terminal kinase, PIP3, phosphatidyl inositol triphosphate.

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