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Figure 6 | Fibrogenesis & Tissue Repair

Figure 6

From: Autocrine transforming growth factor β signaling regulates extracellular signal-regulated kinase 1/2 phosphorylation via modulation of protein phosphatase 2A expression in scleroderma fibroblasts

Figure 6

Protein phosphatase 2A (PP2A) is a negative regulator of collagen expression. (a) Extracts from normal and scleroderma (SSc) dermal fibroblasts were tested for PP2A and collagen expression using western blot analysis. β Actin was used as the loading control; n = 3, representative blot shown. (b) After treatment with okadaic acid (OA; 2 nM) collagen expression was determine using western blot analysis in SSc fibroblasts; n = 3, representative blot shown. (c,d) Normal dermal fibroblasts were treated with PP2A siRNA (100 nM) and collagen mRNA and protein expression measured. β Actin was used as the loading control; n = 3, representative blot shown.

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Fibrogenesis & Tissue Repair

ISSN: 1755-1536

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