Figure 5From: Autocrine transforming growth factor β signaling regulates extracellular signal-regulated kinase 1/2 phosphorylation via modulation of protein phosphatase 2A expression in scleroderma fibroblastsExtracellular signal-regulated kinase (ERK)1/2 phosphorylation is a negative regulator of protein phosphatase 2A (PP2A) expression in scleroderma (SSc) fibroblasts. (a) After treatment with ERK1/2 inhibitor U0126 (10 nm) for 24 h, PP2A expression was determined using western blot analysis in SSc fibroblasts; P < 0.05. (b) Bar graph showing quantification of PP2A expression from (a).Back to article page