Investigation of Toll-like receptors in the pathogenesis of fibrotic and granulomatous disorders: a bronchoalveolar lavage study

Table 5 mRNA expression of TLRs in patient group and control subjects.

	IPF	CTD-IP	Sarcoidosis	Controls	P value
TLR-2	9.75 ± 7.54	4.04 ± 3.53	599.9 ± 597.7	1.72 ± 1.63	NS
TLR-3	0.007 ± 0.005	2.03 ± 2	0.038 ± 0.037	0.0014 ± 0.0008	p1:0.001 p4:0.002 p5:0.05
TLR-4	2.34 ± 1.61	1.35 ± 1.12	20.98 ± 19.3	12.37 ± 12.24	NS
TLR-7	5.06 ± 4.12	12.92 ± 10.25	29 ± 26.81	1.5 ± 1.35	p3:0.05
TLR-8	11.14 ± 7.89	14.5 ± 11.65	679.33 ± 672.34	8.67 ± 8.51	NS
TLR-9	3.1 ± 2.51	1.54 ± 0.94	213.52 ± 211.95	0.58 ± 0.53	p6:0.05

Values are expressed as means ± SEM (standard error of the mean). Mann-Whitney U test; P < 0.05 is considered statistically significant. NS, not significant.
p1: P value between IPF and CTD-IPs, p2: P value between IPF and sarcoidosis, p3: P value between IPF and control, p4: P value between CTD-IP and sarcoidosis, p5: P value between CTD-IP and control, p6: P value between sarcoidosis and control.

ISSN: 1755-1536