Figure 6
Proteinuria and renal function in integrin α2 (ITGA2) knockouts. Electrophoresis of urine proteins reveals middle- and high-molecular weight proteinuria at (b, c) 100 and 150 days compared with (a) healthy wild-type controls. However, the amount of proteinuria in (e) ITGA2 knockouts (triangles) wa s much lower than in COL4A3 knockouts (with ongoing renal failure and nephrotic syndrome; squares). (f) Levels of serum urea of ITGA2 knockouts (triangles) were not significantly different from those of healthy controls (circles) at 100 and 150 days.