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Figure 4 | Fibrogenesis & Tissue Repair

Figure 4

From: Integrin α2-deficient mice provide insights into specific functions of collagen receptors in the kidney

Figure 4

Immunostaining for extracellular matrix and scar tissue. (a-c) EHS laminin; (d, e) fibronectin. Compared with (a) 150-day-old wild-type control mice, (b) 100-day-old and (c) 150-day-old Integrin α2 (ITGA2) knockout mice expressed increased amounts of extracellular matrix. (e) In parallel, 150-day-old ITGA2 knockouts showed accumulation of tubulointerstitial and glomerular scar tissue compared with (d) wild-type mice of the same age.

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