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Figure 4 | Fibrogenesis & Tissue Repair

Figure 4

From: Mast cells and hypoxia drive tissue metaplasia and heterotopic ossification in idiopathic arthrofibrosis after total knee arthroplasty

Figure 4

Immunohistochemical stain of arthrofibrotic tissue for nitrotyrosine, chymase and fibroblast growth factor (FGF). Representative immunohistochemical results are shown for nitrotyrosine in (A) osteoarthritis (OA) tissue and (B) arthrofibrotic tissue, and chymase in (C) OA tissue and (D) arthrofibrotic tissue. (E) Image analysis of mast cell numbers for the low and high bone volume (BV) groups, compared with the OA cohort. There was a significant difference between all three groups (P < 0.05). (F) Representative immunohistochemical result of FGF expression in mast cells.

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