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Table 2 Endogenous basement membrane-derived angiogenesis inhibitors

From: Angiogenesis and chronic kidney disease

Angiogenesis inhibitor Parent protein Domain Receptors Inhibitory activities on EC
Endostatin α1 chain of type XVIII collagen NC1 Glypicans, flk-1, α 5β1-integrin Proliferation, migration, tube formation, survival, tumor growth
Restin α1 chain of type XV collagen NC10 Unknown Proliferation, migration, tumor growth
Tumstatin α3 chain of type IV collagen NC1 αvβ3-integrin Proliferation, tube formation, survival, protein translation, tumor growth
Arresten α1 chain of type IV collagen NC1 α1β1-integrin Proliferation, migration, tube formation, survival, tumor growth
Canstatin α2 chain of type IV collagen NC1 α3β1-integrin Proliferation, migration, tube formation, survival, tumor growth
α6(IV)NC1 α6 chain of type IV collagen NC1 Unknown Proliferation
Endorepellin Perlecan Domain V α 2β1-integrin Migration, tube formation, survival, blood vessel growth in vivo
  1. EC, endothelial cell. ECM, extracellular matrix.