Table 2 Endogenous basement membrane-derived angiogenesis inhibitors
Angiogenesis inhibitor | Parent protein | Domain | Receptors | Inhibitory activities on EC |
|---|---|---|---|---|
Endostatin | α1 chain of type XVIII collagen | NC1 | Glypicans, flk-1, α 5β1-integrin | Proliferation, migration, tube formation, survival, tumor growth |
Restin | α1 chain of type XV collagen | NC10 | Unknown | Proliferation, migration, tumor growth |
Tumstatin | α3 chain of type IV collagen | NC1 | αvβ3-integrin | Proliferation, tube formation, survival, protein translation, tumor growth |
Arresten | α1 chain of type IV collagen | NC1 | α1β1-integrin | Proliferation, migration, tube formation, survival, tumor growth |
Canstatin | α2 chain of type IV collagen | NC1 | α3β1-integrin | Proliferation, migration, tube formation, survival, tumor growth |
α6(IV)NC1 | α6 chain of type IV collagen | NC1 | Unknown | Proliferation |
Endorepellin | Perlecan | Domain V | α 2β1-integrin | Migration, tube formation, survival, blood vessel growth in vivo |