Transplantation of genetically engineered cardiac fibroblasts producing recombinant human erythropoietin to repair the infarcted myocardium

Table 4 Comparison of LV remodeling by postmortem morphometry, 9 weeks after MI

	EPO-transduced cells (n = 10)	Non-transduced cells (n = 9)	Saline (n = 9)	p* ANOVA
LV maximal diameter (mm)	8.2 ± 0.4	6.2 ± 0. 31	8.1 ± 0.33	<0.0001
p (Bonferroni test)	<0.001^†	<0.001^‡	-
Average wall thickness (mm)	1.4 ± 0.05	1.2 ± 0.04	1.4 ± 0.03	0.003
p (Bonferroni test)	<0.05^†	<0.05^‡	-
Average scar thickness (mm)	0.62 ± 0.03	0.92 ± 0.04	1.0 ± 0.05	<0.0001
p (Bonferroni test)	<0.001^§	-	-
Relative scar thickness	0.46 ± 0.05	0.59 ± 0.03	0.56 ± 0.05	0.22
p (Bonferroni test)	-	-	-
Muscle area (mm²)	43 ± 1.4	43 ± 4.2	47 ± 2.3	0.55
p (Bonferroni test)	-	-	-
LV cavity area (mm²)	57 ± 8.0	40 ± 4.9	65 ± 5.3	0.002
p (Bonferroni test)	<0.05^†	<0.01^‡	-
Whole LV area (mm²)	110 ± 7.5	77 ± 7.0	110 ± 7.0	<0.0001
p (Bonferroni test)	< 0.001^†	< 0.001^‡	-
Expansion index	1.1 ± 0.08	0.89 ± 0.05	1.2 ± 0.13	0.04
p (Bonferroni test)	-	<0.05^‡	-
Epicardial scar length (mm)	7.2 ± 1.2	6.5 ± 1.2	8.1 ± 1.6	0.68
p (Bonferroni test)	-	-	-
Endocardial scar length (mm)	7.3 ± 1.6	6.2 ± 1.2	6.6 ± 1.0	0.65
p (Bonferroni test)	-	-	-

Values are means ± SEM. p (Bonferroni test), p-values from Bonferroni multiple comparison test; p*, p-values for the differences between groups (one-way ANOVA). ^†Versus non-transduced cells; ^‡versus saline; ^§versus saline and non-transduced cells.

ISSN: 1755-1536