| |
EPO-transduced cells (n = 10)
|
Non-transduced cells (n = 9)
|
Saline (n = 9)
|
p* ANOVA
|
|---|
|
LV maximal diameter (mm)
|
8.2 ± 0.4
|
6.2 ± 0. 31
|
8.1 ± 0.33
|
<0.0001
|
|
p (Bonferroni test)
|
<0.001†
|
<0.001‡
|
-
| |
|
Average wall thickness (mm)
|
1.4 ± 0.05
|
1.2 ± 0.04
|
1.4 ± 0.03
|
0.003
|
|
p (Bonferroni test)
|
<0.05†
|
<0.05‡
|
-
| |
|
Average scar thickness (mm)
|
0.62 ± 0.03
|
0.92 ± 0.04
|
1.0 ± 0.05
|
<0.0001
|
|
p (Bonferroni test)
|
<0.001§
|
-
|
-
| |
|
Relative scar thickness
|
0.46 ± 0.05
|
0.59 ± 0.03
|
0.56 ± 0.05
|
0.22
|
|
p (Bonferroni test)
|
-
|
-
|
-
| |
|
Muscle area (mm2)
|
43 ± 1.4
|
43 ± 4.2
|
47 ± 2.3
|
0.55
|
|
p (Bonferroni test)
|
-
|
-
|
-
| |
|
LV cavity area (mm2)
|
57 ± 8.0
|
40 ± 4.9
|
65 ± 5.3
|
0.002
|
|
p (Bonferroni test)
|
<0.05†
|
<0.01‡
|
-
| |
|
Whole LV area (mm2)
|
110 ± 7.5
|
77 ± 7.0
|
110 ± 7.0
|
<0.0001
|
|
p (Bonferroni test)
|
< 0.001†
|
< 0.001‡
|
-
| |
|
Expansion index
|
1.1 ± 0.08
|
0.89 ± 0.05
|
1.2 ± 0.13
|
0.04
|
|
p (Bonferroni test)
|
-
|
<0.05‡
|
-
| |
|
Epicardial scar length (mm)
|
7.2 ± 1.2
|
6.5 ± 1.2
|
8.1 ± 1.6
|
0.68
|
|
p (Bonferroni test)
|
-
|
-
|
-
| |
|
Endocardial scar length (mm)
|
7.3 ± 1.6
|
6.2 ± 1.2
|
6.6 ± 1.0
|
0.65
|
|
p (Bonferroni test)
|
-
|
-
|
-
| |
- Values are means ± SEM. p (Bonferroni test), p-values from Bonferroni multiple comparison test; p*, p-values for the differences between groups (one-way ANOVA). †Versus non-transduced cells; ‡versus saline; §versus saline and non-transduced cells.
