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Table 4 Comparison of LV remodeling by postmortem morphometry, 9 weeks after MI

From: Transplantation of genetically engineered cardiac fibroblasts producing recombinant human erythropoietin to repair the infarcted myocardium

  EPO-transduced cells (n = 10) Non-transduced cells (n = 9) Saline (n = 9) p* ANOVA
LV maximal diameter (mm) 8.2 ± 0.4 6.2 ± 0. 31 8.1 ± 0.33 <0.0001
p (Bonferroni test) <0.001 <0.001 -  
Average wall thickness (mm) 1.4 ± 0.05 1.2 ± 0.04 1.4 ± 0.03 0.003
p (Bonferroni test) <0.05 <0.05 -  
Average scar thickness (mm) 0.62 ± 0.03 0.92 ± 0.04 1.0 ± 0.05 <0.0001
p (Bonferroni test) <0.001§ - -  
Relative scar thickness 0.46 ± 0.05 0.59 ± 0.03 0.56 ± 0.05 0.22
p (Bonferroni test) - - -  
Muscle area (mm2) 43 ± 1.4 43 ± 4.2 47 ± 2.3 0.55
p (Bonferroni test) - - -  
LV cavity area (mm2) 57 ± 8.0 40 ± 4.9 65 ± 5.3 0.002
p (Bonferroni test) <0.05 <0.01 -  
Whole LV area (mm2) 110 ± 7.5 77 ± 7.0 110 ± 7.0 <0.0001
p (Bonferroni test) < 0.001 < 0.001 -  
Expansion index 1.1 ± 0.08 0.89 ± 0.05 1.2 ± 0.13 0.04
p (Bonferroni test) - <0.05 -  
Epicardial scar length (mm) 7.2 ± 1.2 6.5 ± 1.2 8.1 ± 1.6 0.68
p (Bonferroni test) - - -  
Endocardial scar length (mm) 7.3 ± 1.6 6.2 ± 1.2 6.6 ± 1.0 0.65
p (Bonferroni test) - - -  
  1. Values are means ± SEM. p (Bonferroni test), p-values from Bonferroni multiple comparison test; p*, p-values for the differences between groups (one-way ANOVA). Versus non-transduced cells; versus saline; §versus saline and non-transduced cells.
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