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Figure 4 | Fibrogenesis & Tissue Repair

Figure 4

From: Transplantation of genetically engineered cardiac fibroblasts producing recombinant human erythropoietin to repair the infarcted myocardium

Figure 4

Four weeks after cell transplantation, rhEPO expression attenuates cardiac cell apoptosis in vivo . (A) Representative photomicrographs of active caspase-3 staining (brown) in infarcted hearts (infarct border zone). Arrows show nuclear active caspase-3 staining. (a) Human tonsil tissue (positive control); (b) saline injection; (c) non-transduced cell injection; (d) rhEPO-transduced cell injection. (B) Representative photomicrographs of TUNEL staining (brown) in infarcted hearts (infarct border zone). (a) Rat mammary gland tissue (positive control); (b) saline injection; (c) non-transduced cell injection; (d) rhEPO-transduced cell injection. (C) Quantitative analysis of apoptosis in infarcted hearts. (a) active caspase-3 staining; (b) TUNEL.

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