Cholecystectomy during the production of extrahepatic cholestasis in mice. The gall bladder is grasped with forceps near the fundus. The cystic artery is divided by caught and then the mesentery is cut with scissors (on top). The gall bladder is held in the left hand and the cystic duct is cleared of soft tissue by gentle blunt dissection. Then, the lobular bile ducts of the median and left lateral lobes (on bottom) are sectioned between ligations.