Figure 10

Relevant examples of redox sensors in prokariotic cells and yeast. In the case of redox sensors described in yeast, the following can apply. The redox sensor Orp-1 of Saccharomyces cerevisiae (Oxidant receptor peroxidase-1, also known as Gpx3) is known to interact with hydrogen peroxide at Cys36, forming a -SOH group that, in turn, will lead to rearrangement (disulphide bonds) in the OxyR analogue Yap1 transcription factor and in the associated Ybp1 protein, leading ultimately to Yap1 nuclear translocation and Yap1-dependent gene activation [18, 71]. Similar systems have also been described in Schizosaccharomyces pombe and a very similar mechanism has been described for PRX-Tpx1.